Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 9, Issue 16, Pages 13819-13824Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.7b02258
Keywords
cancer immunotherapy; natural killer (NK) cells infiltration; interferon-gamma (IFN-gamma); microspheres; and image-guided therapy
Funding
- Medical Scientist Training Program student [T32GM008152]
- Center for Translational Imaging
- Mouse Histology and Phenotyping Laboratory at Northwestern University
- [NIH/NCI-R01CA181658]
- [R21CA173491]
- [R21CA185274]
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The purpose of this research is to develop magnetic resonance imaging (MRI) visible immunomodulatory microspheres (IMM-MS) for efficient image guided cancer immunotherapy. 1MM-MS composed of recombinant interferon gamma (IFN-gamma), iron oxide nanocubes (IONC), and biodegradable poly(lactide-co-glycolide) (PLGA) were successfully prepared via a double-emulsion method. The prepared 1MM-MS exhibited a sustained IFN-gamma release and highly sensitive MR T-2 contrast effects. Finally, in an orthotopic liver tumor VX2 rabbit model, successful hepatic intra-arterial (IA) transcatheter delivery of IMM-MS to liver tumors was confirmed with MR images. The deposition Of EVIM-MS significantly increased NK-cell infiltration into the liver tumor site.
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