Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 9, Issue 16, Pages 13837-13848Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.6b15821
Keywords
antibiotic-resistance; structure-activity relationship; antibacterial mechanism; cationic ligand; biofilms; silver nanoparticles
Funding
- National Natural Science Foundation of China [21474055, 41301624, 51673102]
- Natural Science Foundation of Tianjin City, China [14JYBJC29400]
- Specialized Research Fund for the Doctoral Program of Higher Education [20130031110014]
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To explore The structure-activity relationship of membrane-targeting cationic ligands on a silver nanoparticle surface in an antibiotic-resistant antibacterial and antibiofilm activity assay, a series of functionalized silver nanocomposites were synthesized. Tuning the structural configuration, molecular weight, and side-chain length of the cationic ligands on the nanoparticle surface provided silver nanocomposites with effective antibacterial activity, against both antibiotic resistant Gram-negative and Gram-positive bacteria, including bacterial biofilins. These silver nanocomposites did not trigger hemolytic activity. Significantly; the bacteria did not develop resistance to the obtained nanocomposites even after 30 generations. A. study of the antibacterial mechanism confirmed that these nanocomposites Could irreversibly disrupt the membrane,structure of bacteria and effectively inhibit-intracellular enzyme activity, ultimately leading to bacterial, death. The silver nanocomposites (64 mu g/mL) could eradicate. 80% of an established antibiotic-resistant bacterial biofilm. The strong structure activity relationship toward antibacterial and antibiofilm activity suggests that variations in the conformational prOperty of the functional ligand could be valuable in the discovery of new nano antibacterial agents for treating pathogenic bacterial infections.
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