4.7 Review

Organ-on-a-Chip Technology for Reproducing Multiorgan Physiology

Related references

Note: Only part of the references are listed.
Article Biotechnology & Applied Microbiology

A pumpless multi-organ-on-a-chip (MOC) combined with a pharmacokinetic-pharmacodynamic (PK-PD) model

Hyuna Lee et al.

BIOTECHNOLOGY AND BIOENGINEERING (2017)

Review Neurosciences

Interactions between the microbiota, immune and nervous systems in health and disease

Thomas C. Fung et al.

NATURE NEUROSCIENCE (2017)

Article Multidisciplinary Sciences

Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors

Yu Shrike Zhang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Chemistry, Analytical

Human Liver Sinusoid on a Chip for Hepatitis B Virus Replication Study

Young Bok (Abraham) Kang et al.

MICROMACHINES (2017)

Article Engineering, Biomedical

Design and fabrication of a scalable liver-lobule-on-a-chip microphysiological platform

Amin A. Banaeiyan et al.

BIOFABRICATION (2017)

Article Engineering, Biomedical

Skin integrated with perfusable vascular channels on a chip

Nobuhito Mori et al.

BIOMATERIALS (2017)

Article Biotechnology & Applied Microbiology

Long-term maintenance of a microfluidic 3D human liver sinusoid

Ljupcho Prodanov et al.

BIOTECHNOLOGY AND BIOENGINEERING (2016)

Article Medicine, Research & Experimental

A human liver microphysiology platform for investigating physiology, drug safety, and disease models

Lawrence A. Vernetti et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2016)

Article Multidisciplinary Sciences

Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip

Hyun Jung Kim et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Nanoscience & Nanotechnology

Design and Construction of a Multi-Organ Microfluidic Chip Mimicking the in vivo Microenvironment of Lung Cancer Metastasis

Zhiyun Xu et al.

ACS APPLIED MATERIALS & INTERFACES (2016)

Review Biochemistry & Molecular Biology

The gut-skin axis in health and disease: A paradigm with therapeutic implications

Catherine A. O'Neill et al.

BIOESSAYS (2016)

Article Engineering, Biomedical

Lab on a chip-based hepatic sinusoidal system simulator for optimal primary hepatocyte culture

Yoon Young Choi et al.

BIOMEDICAL MICRODEVICES (2016)

Article Biochemical Research Methods

Microtechnology-based organ systems and whole-body models for drug screening

Seung Hwan Lee et al.

BIOTECHNOLOGY JOURNAL (2016)

Article Medicine, General & Internal

Moody microbes or fecal phrenology: what do we know about the microbiota-gut-brain axis?

Paul Forsythe et al.

BMC MEDICINE (2016)

Review Pharmacology & Pharmacy

Organoid-on-a-chip and body-on-a-chip systems for drug screening and disease modeling

Aleksander Skardal et al.

DRUG DISCOVERY TODAY (2016)

Article Gastroenterology & Hepatology

The Gut Microbiota The Gateway to Improved Metabolism

Kristina B. Martinez et al.

GASTROENTEROLOGY CLINICS OF NORTH AMERICA (2016)

Review Gastroenterology & Hepatology

Sinusoidal communication in liver fibrosis and regeneration

Giusi Marrone et al.

JOURNAL OF HEPATOLOGY (2016)

Review Biochemistry & Molecular Biology

The Gut-Brain Axis, BDNF, NMDA and CNS Disorders

Raeesah Maqsood et al.

NEUROCHEMICAL RESEARCH (2016)

Article Multidisciplinary Sciences

A microfluidics-based in vitro model of the gastrointestinal human-microbe interface

Pranjul Shah et al.

NATURE COMMUNICATIONS (2016)

Article Multidisciplinary Sciences

Development of a Functional Glomerulus at the Organ Level on a Chip to Mimic Hypertensive Nephropathy

Mengying Zhou et al.

SCIENTIFIC REPORTS (2016)

Article Engineering, Biomedical

Human Skin Constructs with Spatially Controlled Vasculature Using Primary and iPSC-Derived Endothelial Cells

Hasan E. Abaci et al.

ADVANCED HEALTHCARE MATERIALS (2016)

Article Biochemical Research Methods

Microtechnology-based organ systems and whole-body models for drug screening

Seung Hwan Lee et al.

BIOTECHNOLOGY JOURNAL (2016)

Article Multidisciplinary Sciences

Investigating Nonalcoholic Fatty Liver Disease in a Liver-on-a-Chip Microfluidic Device

Manuele Gori et al.

PLOS ONE (2016)

Article Engineering, Biomedical

A multilayered microfluidic blood vessel-like structure

Anwarul Hasan et al.

BIOMEDICAL MICRODEVICES (2015)

Review Biotechnology & Applied Microbiology

Recent advances in the use of gelatin in biomedical research

Kai Su et al.

BIOTECHNOLOGY LETTERS (2015)

Article Biochemistry & Molecular Biology

Interaction of Drug or Food with Drug Transporters in Intestine and Liver

Takeo Nakanishi et al.

CURRENT DRUG METABOLISM (2015)

Article Pharmacology & Pharmacy

Chip-based human liver-intestine and liver-skin co-cultures - A first step toward systemic repeated dose substance testing in vitro

Ilka Maschmeyer et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2015)

Review Medicine, Research & Experimental

Gut/brain axis and the microbiota

Emeran A. Mayer et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

Article Biochemical Research Methods

Multi-cellular 3D human primary liver cell culture elevates metabolic activity under fluidic flow

Mandy B. Esch et al.

LAB ON A CHIP (2015)

Letter Biotechnology & Applied Microbiology

Assessing drug safety in human tissues - what are the barriers?

Anthony Holmes et al.

NATURE REVIEWS DRUG DISCOVERY (2015)

Article Multidisciplinary Sciences

A simple coculture system shows mutualism between anaerobic faecalibacteria and epithelial Caco-2 cells

Mehdi Sadaghian Sadabad et al.

SCIENTIFIC REPORTS (2015)

Review Engineering, Biomedical

Microfluidic Organ-on-a-Chip Technology for Advancement of Drug Development and Toxicology

Jeremy D. Caplin et al.

ADVANCED HEALTHCARE MATERIALS (2015)

Article Biochemical Research Methods

An On-Chip Small Intestine-Liver Model for Pharmacokinetic Studies

Hiroshi Kimura et al.

Review Biochemical Research Methods

Human-on-chip for therapy development and fundamental science

Camilla Luni et al.

CURRENT OPINION IN BIOTECHNOLOGY (2014)

Review Pharmacology & Pharmacy

Three dimensional human small intestine models for ADME-Tox studies

Jiajie Yu et al.

DRUG DISCOVERY TODAY (2014)

Article Pharmacology & Pharmacy

A tunable Caco-2/HT29-MTX co-culture model mimicking variable permeabilities of the human intestine obtained by an original seeding procedure

Arnaud Beduneau et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2014)

Review Pharmacology & Pharmacy

Organs-on-a-chip: a new tool for drug discovery

Alessandro Polini et al.

EXPERT OPINION ON DRUG DISCOVERY (2014)

Article Biotechnology & Applied Microbiology

Image-based evaluations of distribution and cytotoxicity of Irinotecan (CPT-11) in a multi-compartment micro-cell coculture device

Hidenari Nakayama et al.

JOURNAL OF BIOSCIENCE AND BIOENGINEERING (2014)

Article Chemistry, Medicinal

Evaluation of a Liver Microfluidic Biochip to Predict In Vivo Clearances of Seven Drugs in Rats

Regis Baudoin et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2014)

Article Biochemical Research Methods

In vitro generation of colonic epithelium from primary cells guided by microstructures

Yuli Wang et al.

LAB ON A CHIP (2014)

Article Medicine, Research & Experimental

3-D Intestinal Scaffolds for Evaluating the Therapeutic Potential of Probiotics

Cait M. Costello et al.

MOLECULAR PHARMACEUTICS (2014)

Article Biotechnology & Applied Microbiology

Microfluidic organs-on-chips

Sangeeta N. Bhatia et al.

NATURE BIOTECHNOLOGY (2014)

Article Biotechnology & Applied Microbiology

Investigation of ifosfamide nephrotoxicity induced in a liver-kidney co-culture biochip

Leila Choucha-Snouber et al.

BIOTECHNOLOGY AND BIOENGINEERING (2013)

Review Biochemical Research Methods

Organ-on-a-chip technology and microfluidic whole-body models for pharmacokinetic drug toxicity screening

Jong Bum Lee et al.

BIOTECHNOLOGY JOURNAL (2013)

Review Biochemistry & Molecular Biology

Voices from within: gut microbes and the CNS

Paul Forsythe et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2013)

Article Cell Biology

On being the right size: scaling effects in designing a human-on-a-chip

Christopher Moraes et al.

INTEGRATIVE BIOLOGY (2013)

Editorial Material Biochemical Research Methods

From molecular structure to tissue architecture: collagen organization probed by SHG microscopy

Riccardo Cicchi et al.

JOURNAL OF BIOPHOTONICS (2013)

Review Gastroenterology & Hepatology

Diet, microbes, and host genetics: the perfect storm in inflammatory bowel diseases

Vanessa Leone et al.

JOURNAL OF GASTROENTEROLOGY (2013)

Article Chemistry, Multidisciplinary

A Microfluidic Device with 3-D Hydrogel Villi Scaffold to Simulate Intestinal Absorption

Si Hyeon Kim et al.

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY (2013)

Editorial Material Biochemical Research Methods

Accelerating drug discovery via organs-on-chips

Chung Yu Chan et al.

LAB ON A CHIP (2013)

Article Biochemical Research Methods

Integrating biological vasculature into a multi-organ-chip microsystem

Katharina Schimek et al.

LAB ON A CHIP (2013)

Article Biochemical Research Methods

Engineering a 3D vascular network in hydrogel for mimicking a nephron

Xuan Mu et al.

LAB ON A CHIP (2013)

Review Chemistry, Physical

Alginate-Based Biomaterials for Regenerative Medicine Applications

Jinchen Sun et al.

MATERIALS (2013)

Article Multidisciplinary Sciences

Cross-talk between E. coli strains and a human colorectal adenocarcinoma-derived cell line

Xuan He et al.

SCIENTIFIC REPORTS (2013)

Article Nanoscience & Nanotechnology

A colorimetric method for the molecular weight determination of polyethylene glycol using gold nanoparticles

Kai Ling et al.

NANOSCALE RESEARCH LETTERS (2013)

Article Engineering, Biomedical

Microfluidic Platforms for Hepatocyte Cell Culture: New Technologies and Applications

Vasiliy N. Goral et al.

ANNALS OF BIOMEDICAL ENGINEERING (2012)

Article Engineering, Biomedical

Microtechnology for Mimicking In Vivo Tissue Environment

Jong Hwan Sung et al.

ANNALS OF BIOMEDICAL ENGINEERING (2012)

Review Biotechnology & Applied Microbiology

Agar degradation by microorganisms and agar-degrading enzymes

Won-Jae Chi et al.

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2012)

Editorial Material Biotechnology & Applied Microbiology

In vitro 3D human small intestinal villous model for drug permeability determination

Jiajie Yu et al.

BIOTECHNOLOGY AND BIOENGINEERING (2012)

Article Biochemical Research Methods

Microengineered physiological biomimicry: Organs-on-Chips

Dongeun Huh et al.

LAB ON A CHIP (2012)

Review Multidisciplinary Sciences

Diversity, stability and resilience of the human gut microbiota

Catherine A. Lozupone et al.

NATURE (2012)

Article Chemistry, Physical

Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues

Jordan S. Miller et al.

NATURE MATERIALS (2012)

Editorial Material Pharmacology & Pharmacy

In vitro human tissue models - moving towards personalized regenerative medicine

Katja Schenke-Layland et al.

ADVANCED DRUG DELIVERY REVIEWS (2011)

Review Engineering, Biomedical

The Role of Body-on-a-Chip Devices in Drug and Toxicity Studies

M. B. Esch et al.

ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 13 (2011)

Article Biochemical Research Methods

Microscale 3-D hydrogel scaffold for biomimetic gastrointestinal (GI) tract model

Jong Hwan Sung et al.

LAB ON A CHIP (2011)

Review Cell Biology

From 3D cell culture to organs-on-chips

Dongeun Huh et al.

TRENDS IN CELL BIOLOGY (2011)

Review Biochemistry & Molecular Biology

Integration of in silico and in vitro platforms for pharmacokinetic-pharmacodynamic modeling

Jong Hwan Sung et al.

EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2010)

Article Biochemical Research Methods

Co-culture of epithelial cells and bacteria for investigating host-pathogen interactions

Jeongyun Kim et al.

LAB ON A CHIP (2010)

Review Biochemical Research Methods

Macro- and microscale fluid flow systems for endothelial cell biology

Edmond W. K. Young et al.

LAB ON A CHIP (2010)

Article Biochemical Research Methods

A microfluidic device for a pharmacokinetic-pharmacodynamic (PK-PD) model on a chip

Jong Hwan Sung et al.

LAB ON A CHIP (2010)

Article Biochemical Research Methods

Perfused multiwell plate for 3D liver tissue engineering

Karel Domansky et al.

LAB ON A CHIP (2010)

Article Chemistry, Analytical

Drug Permeability Assay Using Microhole-Trapped Cells in a Microfluidic Device

Ju Hun Yeon et al.

ANALYTICAL CHEMISTRY (2009)

Article Chemistry, Analytical

A Microfluidic System to Evaluate Intestinal Absorption

Yuki Imura et al.

ANALYTICAL SCIENCES (2009)

Article Engineering, Biomedical

Towards microfabricated biohybrid artificial lung modules for chronic respiratory support

Kristie A. Burgess et al.

BIOMEDICAL MICRODEVICES (2009)

Article Biotechnology & Applied Microbiology

A Novel System for Evaluation of Drug Mixtures for Potential Efficacy in Treating Multidrug Resistant Cancers

Daniel A. Tatosian et al.

BIOTECHNOLOGY AND BIOENGINEERING (2009)

Article Biotechnology & Applied Microbiology

Characterization of a Gastrointestinal Tract Microscale Cell Culture Analog Used to Predict Drug Toxicity

Gretchen J. Mahler et al.

BIOTECHNOLOGY AND BIOENGINEERING (2009)

Article Chemistry, Medicinal

A Combined Pharmacokinetic-Pharmacodynamic (PK-PD) Model for Tumor Growth in the Rat with UFT Administration

Jong Hwan Sung et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2009)

Article Biochemical Research Methods

A microfluidic 3D hepatocyte chip for drug toxicity testing

Yi-Chin Toh et al.

LAB ON A CHIP (2009)

Review Gastroenterology & Hepatology

Principles and clinical implications of the brain-gut-enteric microbiota axis

Sang H. Rhee et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2009)

Review Biochemistry & Molecular Biology

The Caco-2 cell monolayer: usefulness and limitations

Huadong Sun et al.

EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2008)

Review Biochemical Research Methods

Biomolecular gradients in cell culture systems

Thomas M. Keenan et al.

LAB ON A CHIP (2008)

Article Chemistry, Physical

Microfluidic scaffolds for tissue engineering

Nak Won Choi et al.

NATURE MATERIALS (2007)

Article Biotechnology & Applied Microbiology

Induction of zone-like liver function gradients in HepG2 cells by varying culture medium height

James P. Camp et al.

BIOTECHNOLOGY PROGRESS (2007)

Article Biotechnology & Applied Microbiology

An artificial liver sinusoid with a microfluidic endothelial-like barrier for primary hepatocyte culture

Philip J. Lee et al.

BIOTECHNOLOGY AND BIOENGINEERING (2007)

Article Pharmacology & Pharmacy

Intestinal drug transporter expression and the impact of grapefruit juice in humans

H. Glaeser et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2007)

Article Biochemical Research Methods

A novel 3D mammalian cell perfusion-culture system in microfluidic channels

Yi-Chin Toh et al.

LAB ON A CHIP (2007)

Article Biotechnology & Applied Microbiology

Model-based analysis and design of a microchannel reactor for tissue engineering

Khamir Mehta et al.

BIOTECHNOLOGY AND BIOENGINEERING (2006)

Article Peripheral Vascular Disease

Formation of perfused, functional microvascular tubes in vitro

Kenneth M. Chrobak et al.

MICROVASCULAR RESEARCH (2006)

Article Toxicology

In vitro zonation and toxicity in a hepatocyte bioreactor

JW Allen et al.

TOXICOLOGICAL SCIENCES (2005)

Article Biochemistry & Molecular Biology

Cellular uptake and metabolism of flavonoids and their metabolites: implications for their bioactivity

JPE Spencer et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2004)

Article Gastroenterology & Hepatology

The gut-skin axis

U Saarialho-Kere

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION (2004)

Review Pharmacology & Pharmacy

An update on in vitro test methods in human hepatic drug biotransformation research: pros and cons

EFA Brandon et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2003)

Article Biotechnology & Applied Microbiology

Formation of steady-state oxygen gradients in vitro - Application to liver zonation

JW Allen et al.

BIOTECHNOLOGY AND BIOENGINEERING (2003)

Review Cell Biology

Cell interactions with three-dimensional matrices

E Cukierman et al.

CURRENT OPINION IN CELL BIOLOGY (2002)

Article Pharmacology & Pharmacy

The impact of P-glycoprotein efflux on enterocyte residence time and enterocyte-based metabolism of verapamil

BM Johnson et al.

JOURNAL OF PHARMACY AND PHARMACOLOGY (2001)

Article Engineering, Biomedical

Analysis of oxygen transport to hepatocytes in a flat-plate microchannel bioreactor

P Roy et al.

ANNALS OF BIOMEDICAL ENGINEERING (2001)

Article Biotechnology & Applied Microbiology

Combining cell culture analogue reactor designs and PBPK models to probe mechanisms of naphthalene toxicity

A Ghanem et al.

BIOTECHNOLOGY PROGRESS (2000)