Related references
Note: Only part of the references are listed.A pumpless multi-organ-on-a-chip (MOC) combined with a pharmacokinetic-pharmacodynamic (PK-PD) model
Hyuna Lee et al.
BIOTECHNOLOGY AND BIOENGINEERING (2017)
Mimicking liver sinusoidal structures and functions using a 3D-configured microfluidic chip
Yu Du et al.
LAB ON A CHIP (2017)
Interactions between the microbiota, immune and nervous systems in health and disease
Thomas C. Fung et al.
NATURE NEUROSCIENCE (2017)
Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors
Yu Shrike Zhang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Human Liver Sinusoid on a Chip for Hepatitis B Virus Replication Study
Young Bok (Abraham) Kang et al.
MICROMACHINES (2017)
Design and fabrication of a scalable liver-lobule-on-a-chip microphysiological platform
Amin A. Banaeiyan et al.
BIOFABRICATION (2017)
Skin integrated with perfusable vascular channels on a chip
Nobuhito Mori et al.
BIOMATERIALS (2017)
Long-term maintenance of a microfluidic 3D human liver sinusoid
Ljupcho Prodanov et al.
BIOTECHNOLOGY AND BIOENGINEERING (2016)
A human liver microphysiology platform for investigating physiology, drug safety, and disease models
Lawrence A. Vernetti et al.
EXPERIMENTAL BIOLOGY AND MEDICINE (2016)
Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip
Hyun Jung Kim et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Design and Construction of a Multi-Organ Microfluidic Chip Mimicking the in vivo Microenvironment of Lung Cancer Metastasis
Zhiyun Xu et al.
ACS APPLIED MATERIALS & INTERFACES (2016)
On-Chip Construction of Liver Lobule-like Microtissue and Its Application for Adverse Drug Reaction Assay
Chao Ma et al.
ANALYTICAL CHEMISTRY (2016)
The gut-skin axis in health and disease: A paradigm with therapeutic implications
Catherine A. O'Neill et al.
BIOESSAYS (2016)
Lab on a chip-based hepatic sinusoidal system simulator for optimal primary hepatocyte culture
Yoon Young Choi et al.
BIOMEDICAL MICRODEVICES (2016)
Microtechnology-based organ systems and whole-body models for drug screening
Seung Hwan Lee et al.
BIOTECHNOLOGY JOURNAL (2016)
Moody microbes or fecal phrenology: what do we know about the microbiota-gut-brain axis?
Paul Forsythe et al.
BMC MEDICINE (2016)
Organoid-on-a-chip and body-on-a-chip systems for drug screening and disease modeling
Aleksander Skardal et al.
DRUG DISCOVERY TODAY (2016)
The Gut Microbiota The Gateway to Improved Metabolism
Kristina B. Martinez et al.
GASTROENTEROLOGY CLINICS OF NORTH AMERICA (2016)
Three-dimensional models for studying development and disease: moving on from organisms to organs-on-a-chip and organoids
E. L. Jackson et al.
INTEGRATIVE BIOLOGY (2016)
Assessment of metabolism-dependent drug efficacy and toxicity on a multilayer organs-on-a-chip
Zhongyu Li et al.
INTEGRATIVE BIOLOGY (2016)
Sinusoidal communication in liver fibrosis and regeneration
Giusi Marrone et al.
JOURNAL OF HEPATOLOGY (2016)
Modular, pumpless body-on-a-chip platform for the co-culture of GI tract epithelium and 3D primary liver tissue
Mandy B. Esch et al.
LAB ON A CHIP (2016)
The Gut-Brain Axis, BDNF, NMDA and CNS Disorders
Raeesah Maqsood et al.
NEUROCHEMICAL RESEARCH (2016)
Decellularized Human Kidney Cortex Hydrogels Enhance Kidney Microvascular Endothelial Cell Maturation and Quiescence
Ryan J. Nagao et al.
TISSUE ENGINEERING PART A (2016)
A microfluidics-based in vitro model of the gastrointestinal human-microbe interface
Pranjul Shah et al.
NATURE COMMUNICATIONS (2016)
Development of a Functional Glomerulus at the Organ Level on a Chip to Mimic Hypertensive Nephropathy
Mengying Zhou et al.
SCIENTIFIC REPORTS (2016)
Human Skin Constructs with Spatially Controlled Vasculature Using Primary and iPSC-Derived Endothelial Cells
Hasan E. Abaci et al.
ADVANCED HEALTHCARE MATERIALS (2016)
Microtechnology-based organ systems and whole-body models for drug screening
Seung Hwan Lee et al.
BIOTECHNOLOGY JOURNAL (2016)
Investigating Nonalcoholic Fatty Liver Disease in a Liver-on-a-Chip Microfluidic Device
Manuele Gori et al.
PLOS ONE (2016)
Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease
Catherine C. Bell et al.
SCIENTIFIC REPORTS (2016)
Complex, multi-scale small intestinal topography replicated in cellular growth substrates fabricated via chemical vapor deposition of Parylene C
Abigail N. Koppes et al.
BIOFABRICATION (2016)
A multilayered microfluidic blood vessel-like structure
Anwarul Hasan et al.
BIOMEDICAL MICRODEVICES (2015)
Investigation of omeprazole and phenacetin first-pass metabolism in humans using a microscale bioreactor and pharmacokinetic models
Thibault Bricks et al.
BIOPHARMACEUTICS & DRUG DISPOSITION (2015)
Recent advances in the use of gelatin in biomedical research
Kai Su et al.
BIOTECHNOLOGY LETTERS (2015)
Interaction of Drug or Food with Drug Transporters in Intestine and Liver
Takeo Nakanishi et al.
CURRENT DRUG METABOLISM (2015)
Chip-based human liver-intestine and liver-skin co-cultures - A first step toward systemic repeated dose substance testing in vitro
Ilka Maschmeyer et al.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2015)
Human-on-a-chip design strategies and principles for physiologically based pharmacokinetics/pharmacodynamics modeling
Hasan Erbil Abaci et al.
INTEGRATIVE BIOLOGY (2015)
Gut/brain axis and the microbiota
Emeran A. Mayer et al.
JOURNAL OF CLINICAL INVESTIGATION (2015)
Multi-cellular 3D human primary liver cell culture elevates metabolic activity under fluidic flow
Mandy B. Esch et al.
LAB ON A CHIP (2015)
Assessing drug safety in human tissues - what are the barriers?
Anthony Holmes et al.
NATURE REVIEWS DRUG DISCOVERY (2015)
A simple coculture system shows mutualism between anaerobic faecalibacteria and epithelial Caco-2 cells
Mehdi Sadaghian Sadabad et al.
SCIENTIFIC REPORTS (2015)
Microfluidic Organ-on-a-Chip Technology for Advancement of Drug Development and Toxicology
Jeremy D. Caplin et al.
ADVANCED HEALTHCARE MATERIALS (2015)
An On-Chip Small Intestine-Liver Model for Pharmacokinetic Studies
Hiroshi Kimura et al.
JALA (2015)
First Pass Intestinal and Liver Metabolism of Paracetamol in a Microfluidic Platform Coupled With a Mathematical Modeling as a Means of Evaluating ADME Processes in Humans
Jean Matthieu Prot et al.
BIOTECHNOLOGY AND BIOENGINEERING (2014)
Human-on-chip for therapy development and fundamental science
Camilla Luni et al.
CURRENT OPINION IN BIOTECHNOLOGY (2014)
Three dimensional human small intestine models for ADME-Tox studies
Jiajie Yu et al.
DRUG DISCOVERY TODAY (2014)
A tunable Caco-2/HT29-MTX co-culture model mimicking variable permeabilities of the human intestine obtained by an original seeding procedure
Arnaud Beduneau et al.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2014)
Organs-on-a-chip: a new tool for drug discovery
Alessandro Polini et al.
EXPERT OPINION ON DRUG DISCOVERY (2014)
Three-dimensional intestinal villi epithelium enhances protection of human intestinal cells from bacterial infection by inducing mucin expression
Si Hyun Kim et al.
INTEGRATIVE BIOLOGY (2014)
Image-based evaluations of distribution and cytotoxicity of Irinotecan (CPT-11) in a multi-compartment micro-cell coculture device
Hidenari Nakayama et al.
JOURNAL OF BIOSCIENCE AND BIOENGINEERING (2014)
Evaluation of a Liver Microfluidic Biochip to Predict In Vivo Clearances of Seven Drugs in Rats
Regis Baudoin et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2014)
In vitro generation of colonic epithelium from primary cells guided by microstructures
Yuli Wang et al.
LAB ON A CHIP (2014)
Body-on-a-chip simulation with gastrointestinal tract and liver tissues suggests that ingested nanoparticles have the potential to cause liver injury
Mandy B. Esch et al.
LAB ON A CHIP (2014)
3-D Intestinal Scaffolds for Evaluating the Therapeutic Potential of Probiotics
Cait M. Costello et al.
MOLECULAR PHARMACEUTICS (2014)
Microfluidic organs-on-chips
Sangeeta N. Bhatia et al.
NATURE BIOTECHNOLOGY (2014)
Development of a new microfluidic platform integrating co-cultures of intestinal and liver cell lines
Thibault Bricks et al.
TOXICOLOGY IN VITRO (2014)
Investigation of ifosfamide nephrotoxicity induced in a liver-kidney co-culture biochip
Leila Choucha-Snouber et al.
BIOTECHNOLOGY AND BIOENGINEERING (2013)
Organ-on-a-chip technology and microfluidic whole-body models for pharmacokinetic drug toxicity screening
Jong Bum Lee et al.
BIOTECHNOLOGY JOURNAL (2013)
Voices from within: gut microbes and the CNS
Paul Forsythe et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2013)
On being the right size: scaling effects in designing a human-on-a-chip
Christopher Moraes et al.
INTEGRATIVE BIOLOGY (2013)
Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation
Hyun Jung Kim et al.
INTEGRATIVE BIOLOGY (2013)
From molecular structure to tissue architecture: collagen organization probed by SHG microscopy
Riccardo Cicchi et al.
JOURNAL OF BIOPHOTONICS (2013)
Diet, microbes, and host genetics: the perfect storm in inflammatory bowel diseases
Vanessa Leone et al.
JOURNAL OF GASTROENTEROLOGY (2013)
A Microfluidic Device with 3-D Hydrogel Villi Scaffold to Simulate Intestinal Absorption
Si Hyeon Kim et al.
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY (2013)
Microfabricated mammalian organ systems and their integration into models of whole animals and humans
Jong H. Sung et al.
LAB ON A CHIP (2013)
Characterization of drug permeability in Caco-2 monolayers by mass spectrometry on a membrane-based microfluidic device
Dan Gao et al.
LAB ON A CHIP (2013)
Accelerating drug discovery via organs-on-chips
Chung Yu Chan et al.
LAB ON A CHIP (2013)
Integrating biological vasculature into a multi-organ-chip microsystem
Katharina Schimek et al.
LAB ON A CHIP (2013)
Three-dimensional co-cultures of human endothelial cells and embryonic stem cell-derived pericytes inside a microfluidic device
Andries D. van der Meer et al.
LAB ON A CHIP (2013)
A dynamic multi-organ-chip for long-term cultivation and substance testing proven by 3D human liver and skin tissue co-culture
Ilka Wagner et al.
LAB ON A CHIP (2013)
Engineering a 3D vascular network in hydrogel for mimicking a nephron
Xuan Mu et al.
LAB ON A CHIP (2013)
Alginate-Based Biomaterials for Regenerative Medicine Applications
Jinchen Sun et al.
MATERIALS (2013)
Cross-talk between E. coli strains and a human colorectal adenocarcinoma-derived cell line
Xuan He et al.
SCIENTIFIC REPORTS (2013)
A colorimetric method for the molecular weight determination of polyethylene glycol using gold nanoparticles
Kai Ling et al.
NANOSCALE RESEARCH LETTERS (2013)
Comparison of Biocompatibility and Adsorption Properties of Different Plastics for Advanced Microfluidic Cell and Tissue Culture Models
Paul M. van Midwoud et al.
ANALYTICAL CHEMISTRY (2012)
Micro Total Bioassay System for Oral Drugs: Evaluation of Gastrointestinal Degradation, Intestinal Absorption, Hepatic Metabolism, and Bioactivity
Yuki Imura et al.
ANALYTICAL SCIENCES (2012)
Microfluidic Platforms for Hepatocyte Cell Culture: New Technologies and Applications
Vasiliy N. Goral et al.
ANNALS OF BIOMEDICAL ENGINEERING (2012)
Microtechnology for Mimicking In Vivo Tissue Environment
Jong Hwan Sung et al.
ANNALS OF BIOMEDICAL ENGINEERING (2012)
Agar degradation by microorganisms and agar-degrading enzymes
Won-Jae Chi et al.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2012)
Controlled formation of heterotypic hepatic micro-organoids in anisotropic hydrogel microfibers for long-term preservation of liver-specific functions
Masumi Yamada et al.
BIOMATERIALS (2012)
On chip porous polymer membranes for integration of gastrointestinal tract epithelium with microfluidic 'body-on-a-chip' devices
Mandy Brigitte Esch et al.
BIOMEDICAL MICRODEVICES (2012)
In vitro 3D human small intestinal villous model for drug permeability determination
Jiajie Yu et al.
BIOTECHNOLOGY AND BIOENGINEERING (2012)
In vitro formation and characterization of a perfusable three-dimensional tubular capillary network in microfluidic devices
Ju Hun Yeon et al.
LAB ON A CHIP (2012)
Microengineered physiological biomimicry: Organs-on-Chips
Dongeun Huh et al.
LAB ON A CHIP (2012)
Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow
Hyun Jung Kim et al.
LAB ON A CHIP (2012)
Diversity, stability and resilience of the human gut microbiota
Catherine A. Lozupone et al.
NATURE (2012)
Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues
Jordan S. Miller et al.
NATURE MATERIALS (2012)
Glucose and Fatty Acid Metabolism in a 3 Tissue In-Vitro Model Challenged with Normo- and Hyperglycaemia
Elisabetta Iori et al.
PLOS ONE (2012)
In vitro human tissue models - moving towards personalized regenerative medicine
Katja Schenke-Layland et al.
ADVANCED DRUG DELIVERY REVIEWS (2011)
The Role of Body-on-a-Chip Devices in Drug and Toxicity Studies
M. B. Esch et al.
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 13 (2011)
The physiological performance of a three-dimensional model that mimics the microenvironment of the small intestine
Jacqueline Pusch et al.
BIOMATERIALS (2011)
Diffusion-mediated in situ alginate encapsulation of cell spheroids using microscale concave well and nanoporous membrane
Kwang Ho Lee et al.
LAB ON A CHIP (2011)
Microscale 3-D hydrogel scaffold for biomimetic gastrointestinal (GI) tract model
Jong Hwan Sung et al.
LAB ON A CHIP (2011)
From 3D cell culture to organs-on-chips
Dongeun Huh et al.
TRENDS IN CELL BIOLOGY (2011)
Micro Total Bioassay System for Ingested Substances: Assessment of Intestinal Absorption, Hepatic Metabolism, and Bioactivity
Yuki Imura et al.
ANALYTICAL CHEMISTRY (2010)
Synergic effects of crypt-like topography and ECM proteins on intestinal cell behavior in collagen based membranes
Lin Wang et al.
BIOMATERIALS (2010)
An In Vitro Study on Bacterial Growth Interactions and Intestinal Epithelial Cell Adhesion Characteristics of Probiotic Combinations
Mahta Moussavi et al.
CURRENT MICROBIOLOGY (2010)
Integration of in silico and in vitro platforms for pharmacokinetic-pharmacodynamic modeling
Jong Hwan Sung et al.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2010)
Co-culture of epithelial cells and bacteria for investigating host-pathogen interactions
Jeongyun Kim et al.
LAB ON A CHIP (2010)
Macro- and microscale fluid flow systems for endothelial cell biology
Edmond W. K. Young et al.
LAB ON A CHIP (2010)
A microfluidic device for a pharmacokinetic-pharmacodynamic (PK-PD) model on a chip
Jong Hwan Sung et al.
LAB ON A CHIP (2010)
Perfusion-based microfluidic device for three-dimensional dynamic primary human hepatocyte cell culture in the absence of biological or synthetic matrices or coagulants
Vasiliy N. Goral et al.
LAB ON A CHIP (2010)
Perfused multiwell plate for 3D liver tissue engineering
Karel Domansky et al.
LAB ON A CHIP (2010)
A microfluidic approach for in vitro assessment of interorgan interactions in drug metabolism using intestinal and liver slices
Paul M. van Midwoud et al.
LAB ON A CHIP (2010)
Drug Permeability Assay Using Microhole-Trapped Cells in a Microfluidic Device
Ju Hun Yeon et al.
ANALYTICAL CHEMISTRY (2009)
A Microfluidic System to Evaluate Intestinal Absorption
Yuki Imura et al.
ANALYTICAL SCIENCES (2009)
Influence of micro-well biomimetic topography on intestinal epithelial Caco-2 cell phenotype
Lin Wang et al.
BIOMATERIALS (2009)
Towards microfabricated biohybrid artificial lung modules for chronic respiratory support
Kristie A. Burgess et al.
BIOMEDICAL MICRODEVICES (2009)
A Novel System for Evaluation of Drug Mixtures for Potential Efficacy in Treating Multidrug Resistant Cancers
Daniel A. Tatosian et al.
BIOTECHNOLOGY AND BIOENGINEERING (2009)
Characterization of a Gastrointestinal Tract Microscale Cell Culture Analog Used to Predict Drug Toxicity
Gretchen J. Mahler et al.
BIOTECHNOLOGY AND BIOENGINEERING (2009)
A Combined Pharmacokinetic-Pharmacodynamic (PK-PD) Model for Tumor Growth in the Rat with UFT Administration
Jong Hwan Sung et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2009)
A microfluidic 3D hepatocyte chip for drug toxicity testing
Yi-Chin Toh et al.
LAB ON A CHIP (2009)
Principles and clinical implications of the brain-gut-enteric microbiota axis
Sang H. Rhee et al.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2009)
Fabrication of an artificial 3-dimensional vascular network using sacrificial sugar structures
Leon M. Bellan et al.
SOFT MATTER (2009)
The Caco-2 cell monolayer: usefulness and limitations
Huadong Sun et al.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2008)
Biomolecular gradients in cell culture systems
Thomas M. Keenan et al.
LAB ON A CHIP (2008)
An integrated microfluidic system for long-term perfusion culture and on-line monitoring of intestinal tissue models
Hiroshi Kimura et al.
LAB ON A CHIP (2008)
Microfluidic scaffolds for tissue engineering
Nak Won Choi et al.
NATURE MATERIALS (2007)
Induction of zone-like liver function gradients in HepG2 cells by varying culture medium height
James P. Camp et al.
BIOTECHNOLOGY PROGRESS (2007)
An artificial liver sinusoid with a microfluidic endothelial-like barrier for primary hepatocyte culture
Philip J. Lee et al.
BIOTECHNOLOGY AND BIOENGINEERING (2007)
Trends in the development of microfluidic cell biochips for in vitro hepatotoxicity
Regis Baudoin et al.
TOXICOLOGY IN VITRO (2007)
Quantitative measurements of the strength of adhesion of human neutrophils to a substratum in a microfluidic device
Edgar Gutierrez et al.
ANALYTICAL CHEMISTRY (2007)
Intestinal drug transporter expression and the impact of grapefruit juice in humans
H. Glaeser et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2007)
A novel 3D mammalian cell perfusion-culture system in microfluidic channels
Yi-Chin Toh et al.
LAB ON A CHIP (2007)
Model-based analysis and design of a microchannel reactor for tissue engineering
Khamir Mehta et al.
BIOTECHNOLOGY AND BIOENGINEERING (2006)
Formation of perfused, functional microvascular tubes in vitro
Kenneth M. Chrobak et al.
MICROVASCULAR RESEARCH (2006)
In vitro zonation and toxicity in a hepatocyte bioreactor
JW Allen et al.
TOXICOLOGICAL SCIENCES (2005)
The effects of epidermal keratinocytes and dermal fibroblasts on the formation of cutaneous basement membrane in three-dimensional culture systems
DY Lee et al.
ARCHIVES OF DERMATOLOGICAL RESEARCH (2005)
Glucose permeable poly (dimethyl siloxane) poly (N-isopropyl acrylamide) interpenetrating networks as ophthalmic biomaterials
L Liu et al.
BIOMATERIALS (2005)
Enhanced cytochrome P450 capacities of Caco-2 and Hep G2 cells in new coculture system under the static and perfused conditions: evidence for possible organ-to-organ interactions against exogenous stimuli
SH Choi et al.
MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS (2004)
Cellular uptake and metabolism of flavonoids and their metabolites: implications for their bioactivity
JPE Spencer et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2004)
The gut-skin axis
U Saarialho-Kere
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION (2004)
Usefulness of a novel caco-2 cell perfusion system.: 1.: In vitro prediction of the absorption potential of passively diffused compounds
C Masungi et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2004)
An update on in vitro test methods in human hepatic drug biotransformation research: pros and cons
EFA Brandon et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2003)
Formation of steady-state oxygen gradients in vitro - Application to liver zonation
JW Allen et al.
BIOTECHNOLOGY AND BIOENGINEERING (2003)
Cell interactions with three-dimensional matrices
E Cukierman et al.
CURRENT OPINION IN CELL BIOLOGY (2002)
The impact of P-glycoprotein efflux on enterocyte residence time and enterocyte-based metabolism of verapamil
BM Johnson et al.
JOURNAL OF PHARMACY AND PHARMACOLOGY (2001)
Analysis of oxygen transport to hepatocytes in a flat-plate microchannel bioreactor
P Roy et al.
ANNALS OF BIOMEDICAL ENGINEERING (2001)
Characterizing the expression of CYP3A4 and efflux transporters (P-gp, MRP1, and MRP2) in CYP3A4-transfected Caco-2 cells after induction with sodium butyrate and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate
CL Cummins et al.
PHARMACEUTICAL RESEARCH (2001)
Combining cell culture analogue reactor designs and PBPK models to probe mechanisms of naphthalene toxicity
A Ghanem et al.
BIOTECHNOLOGY PROGRESS (2000)