Journal
ADVANCED HEALTHCARE MATERIALS
Volume 6, Issue 7, Pages -Publisher
WILEY
DOI: 10.1002/adhm.201601289
Keywords
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Funding
- State Key Project of Research and Development [2016YFC1100300]
- National Natural Science Foundation of China [51273047, 51473037]
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The pursuit of multifunctional, innovative, more efficient, and safer cancer treatment has gained increasing interest in the research of preclinical nanoparticle-mediated photothermal therapy (PTT). Cell nucleus is recognized as the ideal target for cancer treatment because it plays a central role in genetic information and the transcription machinery reside. In this work, an efficient nuclear-targeted PTT strategy is proposed using transferrin and TAT peptide (TAT: YGRKKRRQRRR) conjugated monodisperse magnetic nanoparticles, which can be readily functionalized and stabilized for potential diagnostic and therapeutic applications. The monodisperse magnetic nanoparticles exhibit high photothermal conversion efficiency (approximate to 37%) and considerable photothermal stability. They also show a high magnetization value and transverse relaxivity (207.1 mm(-1) s(-1)), which could be applied for magnetic resonance imaging. The monodisperse magnetic nanoparticles conjugated with TAT peptides can efficiently target the nucleus and achieve the imaging-guided function, efficient cancer cells killing ability. Therefore, this work may present a practicable strategy to develop subcellular organelle targeted PTT agents for simultaneous cancer targeting, imaging, and therapy.
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