Journal
ADVANCED HEALTHCARE MATERIALS
Volume 6, Issue 8, Pages -Publisher
WILEY
DOI: 10.1002/adhm.201601269
Keywords
biocompatibility; biodegradable; corrosion; magnesium; polycaprolactone
Funding
- AO Trauma Research Grant
- Hong Kong Research Grant Council General Research Funds (RGC GRF) [718913, 772113, 17214516, 112212]
- City University of Hong Kong Strategic Research Grant (SRG) [7004188]
- HKU Seeding Fund [201309176106, 201411159045]
- Hong Kong Innovation Technology Fund [ITS/147/15]
- Hong Kong Health and Medical Research Fund [03142446]
- National Natural Science Foundation of China (NSFC) [31370957, 51422102, 81572113]
- Ministry of Science and Technology of China [2014CB660809]
- Shenzhen Innovative Technology Commission [JCYJ20140414090541811, JCYJ20160429185449249]
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To achieve enhanced biological response and controlled degradation of magnesium alloy, a modified biodegradable polymer coating called polycaprolactone (PCL) is fabricated by a thermal approach in which the heat treatment neither alters the chemical composition of the PCL membrane nor the rate of magnesium ion release, pH value, or weight loss, compared with the untreated sample. The changes in the crystallinity, hydrophilicity, and oxygen content of heat-treated PCL coating not only improve the mechanical adhesion strength between the coating and magnesium substrate but also enhance the biological properties. Moreover, the thermally modified sample can lead to higher spreading and elongation of osteoblasts, due to the enhanced hydrophilicity and CO to CO functional group ratio. In the analyses of microcomputed tomography from one to four weeks postoperation, the total volume of new bone formation on the heat-treated sample is 10%-35% and 70%-90% higher than that of the untreated and uncoated controls, respectively. Surprisingly, the indentation modulus of the newly formed bone adjacent to the heat-treated sample is approximate to 20% higher than that of both controls. These promising results reveal the clinical potential of the modified PCL coating on magnesium alloy in orthopedic applications.
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