Journal
AUTOIMMUNITY REVIEWS
Volume 16, Issue 6, Pages 587-593Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.autrev.2017.04.004
Keywords
Sjogren syndrome; Vitamin D; Immunomodulation; Environment
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The immunomodulatory effects of vitamin D have been extensively studied in the context of autoimmunity. Multiple studies have demonstrated a high prevalence of vitamin D deficiency in autoimmune diseases. Recently, a possible protective role of vitamin D in autoimmunity has been described; however, this function remains controversial. Few studies have investigated the role of vitamin D in patients with Sjogren syndrome (SS). In this review, we compiled the main features of SS pathogenesis, the vitamin D immunomodulatory effects and the possible interaction between both. Data suggests that vitamin D may play a role in the SS pathogenesis. In addition, vitamin D low levels have been found in SS patients, which are associated with extra-glandular manifestations, such as lymphoma or neuropathy, suggesting a possible benefit effect of vitamin D in SS. (C) 2017 Elsevier B.V. All rights reserved.
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