Journal
BMB REPORTS
Volume 50, Issue 4, Pages 175-185Publisher
KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
DOI: 10.5483/BMBRep.2017.50.4.015
Keywords
Cellular pathway; Nonsense mutations; Nonsense-mediated mRNA decay (NMD); Quality control mechanism; UPF proteins
Categories
Funding
- Association Francaise contre les Myopathies
- CNRS
- Vaincre la mucoviscidose
- Canceropole Nord-Ouest
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Nonsense-mediated mRNA decay (NMD) is a surveillance mechanism ensuring the fast decay of mRNAs harboring a premature termination codon (PTC). As a quality control mechanism, NMD distinguishes PTCs from normal termination codons in order to degrade PTC-carrying mRNAs only. For this, NMD is connected to various other cell processes which regulate or activate it under specific cell conditions or in response to mutations, mis-regulations, stresses, or particular cell programs. These cell processes and their connections with NMD are the focus of this review, which aims both to illustrate the complexity of the NMD mechanism and its regulation and to highlight the cellular consequences of NMD inhibition.
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