Journal
BMB REPORTS
Volume 50, Issue 4, Pages 208-213Publisher
KOREAN SOCIETY BIOCHEMISTRY & MOLECULAR BIOLOGY
DOI: 10.5483/BMBRep.2017.50.4.165
Keywords
Cardiac hypertrophy; cGMP-dependent protein kinase-1; MicroRNA; Neonatal rat ventricular myocytes; Vascular endothelial growth factor signaling
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Funding
- GIST Research Institute (GRI) Grant
- National Research Foundation of Korea (NRF) - Korean government, the Ministry of Science, ICT, & Future Planning [NRF-2013M3A9A7046297]
- Ministry of Science, ICT, & Future Planning [NRF-2013M3A9A7046297]
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Vascular endothelial growth factor (VEGF) is an essential cytokine that has functions in the formation of new blood vessels and regression of cardiac hypertrophy. VEGF/VEGF-receptor-1 (VEGFR1) signaling plays a key role in the regression of cardiac hypertrophy, whereas VEGF/VEGFR2 signaling leads to cardiac hypertrophy. In this study, we identified the prohypertrophic role of miR-374 using neonatal rat ventricular myocytes (NRVMs). Our results showed that overexpression of miR-374 activated G protein-coupled receptor-mediated prohypertrophic pathways by the inhibition of VEGFR1-dependent regression pathways. Luciferase assays revealed that miR-374 could directly target the 3'-untranslated regions of VEGFR1 and cGMP-dependent protein kinase-1. Collectively, these findings demonstrated that miR-374 was a novel pro-hypertrophic microRNA functioning to suppress the VEGFR1-mediated regression pathway.
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