Journal
ADVANCED HEALTHCARE MATERIALS
Volume 7, Issue 7, Pages -Publisher
WILEY
DOI: 10.1002/adhm.201701096
Keywords
biomaterials; drug delivery; mechanoresponsive; protein delivery; superhydrophobic
Funding
- National Institutes of Health [T32 EB006359, R01EB017722]
- National Science Foundation [DGE-1247312]
- Wallace H. Coulter Translational Partnership
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The fabrication and performance of mechanically responsive multilayer superhydrophobic composites are reported. The application of tensile strain triggers the release of small molecules and proteins from these composites, with different tensile strain magnitudes and coating thickness influencing agent release. These mechanoresponsive composites consist of an absorbent drug core surrounded by an electrosprayed superhydrophobic protective coating that limits drug release in the absence of tensile strain. Coating thickness and applied tensile strain control release of chemotherapeutic cisplatin and enzyme beta-galactosidase, as measured by atomic absorption and UV-vis spectrophotometry, respectively, with preserved in vitro activity. Such mechanically responsive drug delivery devices, when coupled to existing dynamic mechanical forces in the body or integrated with mechanical medical devices, such as stents, will provide local controlled dosing.
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