Journal
ACS MACRO LETTERS
Volume 6, Issue 12, Pages 1379-1385Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsmacrolett.7b00836
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Funding
- EPSRC Platform grant [EP/J007846/1]
- ERC five-year Advanced Investigator grant [PISA 320372]
- National Science Foundation of China [21674086, 21374088]
- Fundamental Research Funds for the Central Universities [3102017jc03006, 3102017jc01001]
- Graduate School of Northwestern Polytechnical University
- EPSRC [EP/J007846/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/J007846/1] Funding Source: researchfish
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Hostguest chemistry is exploited to tune the rate at which block copolymer vesicles undergo morphological transitions. More specifically, a concentrated aqueous dispersion of poly(glycerol monomethacrylate-co-glycidyl methacrylate)poly(2-hydroxypropyl methacrylate) [P(GMA-co-GlyMA)-PHPMA] diblock copolymer vesicles was prepared via polymerization-induced self-assembly (PISA). The epoxy groups in the GlyMA residues were ring-opened using a primary amine-functionalized beta-cyclodextrin (NH2-beta-CD) in order to prepare beta-CD-decorated vesicles. Addition of azobenzene-methoxypoly(ethylene glycol) (azo-mPEG) to such vesicles results in specific binding of this water-soluble macromolecular reagent to the beta-CD groups on the hydrophilic P(GMA-co-GlyMA) stabilizer chains. Such hostguest chemistry induces a morphological transition from vesicles to worms and/or spheres. Furthermore, the rate of this morphological transition can be tuned by UV/visible-light irradiation and/or guest molecule competition. This novel molecular recognition strategy offers considerable scope for the design of new stimulus-responsive diblock copolymer vesicles for targeted delivery and controlled release of cargoes.
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