Journal
ACS MACRO LETTERS
Volume 6, Issue 7, Pages 695-699Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsmacrolett.7b00396
Keywords
-
Categories
Funding
- DARPA [N66001-15-2-4023]
- NSF [CHE-1565810]
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1565810] Funding Source: National Science Foundation
Ask authors/readers for more resources
Nontoxic cryoprotectants are needed for storage of tissues and food preservation. Frozen tissue is particularly susceptible to damage caused by formation of large ice crystals during the thawing process. The current practice of using 5 wt % DMSO for cryopreservation does not produce 100% cell viability post-thaw, at least in part because of DMSO toxicity that is manifested during the freezing and thawing stages of the process. Recently, poly(vinyl alcohol) (PVA) has shown promise in inhibiting ice recrystallization, an activity that is critical for cryoprotection. Inspired by this discovery, we have evaluated nylon-3 polymers for ice recrystallization inhibition activity and for toxicity toward mammalian cells. A survey of homo- and heteropolymers, with side chains bearing variable functionality, has identified new nylon-3 materials that display excellent ice recrystallization inhibition activity and low toxicity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available