Journal
ACS MACRO LETTERS
Volume 6, Issue 9, Pages 1005-1012Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsmacrolett.7b00490
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Funding
- NSF-CMMI Nanomanufacturing program CAREER award [1350731]
- NSF-DMR CAREER award [11515135]
- DOE Office of Science [DE-AC02-06CH11357]
- National Institute of General Medical Sciences of the National Institutes of Health [9 P41 GM103622]
- NIGMS [1S10OD018090-01]
- Northwestern University
- E.I. DuPont de Nemours Co.
- Dow Chemical Company
- National Science Foundation [0960140]
- Direct For Mathematical & Physical Scien
- Division Of Materials Research [1151535] Funding Source: National Science Foundation
- Div Of Civil, Mechanical, & Manufact Inn
- Directorate For Engineering [1350731] Funding Source: National Science Foundation
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A large group of functional nanomaterials employed in biomedical applications, including targeted drug delivery, relies on amphiphilic polymers to encapsulate therapeutic payloads via self-assembly processes. Knowledge of the micelle structures will provide critical insights into design of polymeric drug delivery systems. Core shell micelles composed of linear diblock copolymers poly(ethylene glycol)-b-poly(caprolactone) (PEG-b-PCL), poly(ethylene oxide)-b-poly(lactic acid) (PEG-b-PLA), as well as a heterografted brush consisting of a poly(glycidyl methacrylate) backbone with PEG and PLA branches (PGMA-g-PEG/PLA) were characterized by dynamic light scattering (DLS) and small-angle X-ray scattering (SAXS) measurements to gain structural information regarding the particle morphology, core-shell size, and aggregation number. The structural information at this quasi-equilibrium state can also be used as a reference when studying the kinetics of polymer micellization.
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