Journal
ACS MACRO LETTERS
Volume 6, Issue 3, Pages 219-223Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsmacrolett.6b00966
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Funding
- National Science Foundation [DMR-1507429, DMR-1309724]
- Welch Foundation [A-0001]
- Direct For Mathematical & Physical Scien
- Division Of Materials Research [1507429] Funding Source: National Science Foundation
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [1309724] Funding Source: National Science Foundation
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The direct and facile synthesis of polyphosphoramidates (PPAs) with acid-labile phosphoramidate backbone linkages are reported, together with demonstration of their hydrolytic degradability, evaluated under acidic conditions. The introduction of acid-labile linkages along the polymer backbone led to rapid degradation of the polymer backbone dependent upon the environmental stimuli. An oxazaphospholidine monomer bearing a phosphoramidate linkage was designed and synthesized to afford the PPAs via organobase-catalyzed ring-opening polymerization in a controlled manner. The hydrolytic degradation of the PPAs was studied, revealing breakdown of the polymer backbone through cleavage of the phosphorarnidate linkages under acidic conditions.
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