Journal
CURRENT MEDICINAL CHEMISTRY
Volume 24, Issue 9, Pages 918-927Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929867324666170214110633
Keywords
Vitamin D; gastrointestinal cancer; cancer stem cells; cancer stem cell markers; cancer microenvironment
Funding
- General Research Fund from the Hong Kong Research Grant Council [CUHK 463613]
- Health and Medical Research Fund from the Food and Health Bureau in Hong Kong [13120062]
- National Natural Science Foundation of China [81473269]
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Vitamin D has been widely used as a dietary supplement for the prevention and treatment of bone disorders. Epidemiological and preclinical studies demonstrated the anticancer action of vitamin D in a variety of cancers including those in the gastrointestinal (GI) tract. In these studies the inhibitory action of vitamin D on cancer stem cells (CSCs) has been a focus and is also an important subject to revolutionize the therapeutic potential of vitamin D on cancer treatment. Here, we summarize the involvement of CSC markers and factors and also their signaling pathways in the development of cancers in the esophagus, stomach, colon, pancreas and also liver. It is also evidenced that vitamin D could inhibit these markers and factors and their related signaling pathways to suppress tumor progression. All these information could provide new strategies in repurposing vitamin D as therapeutic agent to inhibit cancers in the GI tract.
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