Journal
WORLD NEUROSURGERY
Volume 107, Issue -, Pages 168-174Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/J.WNEU.2017.07.136
Keywords
Deep brain stimulation; Diffusion tensor imaging; MRI; Targeting; Thalamus; Tremor
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Funding
- Medtronic
- Boston Scientific
- St. Jude Medical, Inc.
- Eli Lilly and Company
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BACKGROUND: Thalamic deep brain stimulation (DBS) is an effective strategy for treatment of essential tremor (ET). With limitations of imaging modalities, targeting largely relies on indirect methods. This study was designed to determine the optimal target for DBS in ET and construct a targeting method based on probabilistic maps. METHODS: Patients with ET who had sustained tremor reduction at 1 year and optimal microelectrode recordings were selected. Stimulation volume was individually modeled in standard space, and a final optimal region was derived for the whole population. A fornix (FX) targeting method was developed to determine the location of the optimal stimulation site relative to the FX and posterior commissure (PC) in the anteroposterior plane, the border between the thalamus and internal capsule in the medio-lateral plane, and the anterior commissure (AC)-PC (AC-PC) plane in the dorsoventral axis. Following comparative analyses with other standard indirect methods (25% of AC-PC and PC + 6 mm), the FX method was studied in relation to diffusion tensor imaging. RESULTS: Using the FX method, the optimal stimulation site was at the intersection of two thirds and one third of the PC-FX distance (mean of 28% +/- 1.5 AC-PC length) and 4 mm medial to the lateral border of the thalamus. Compared with previously used methods, there was a significant reduction in variability of the optimal stimulation site with the FX method. The target defined using this strategy was found to be within the boundaries of the dentatorubrothalamic tract. - CONCLUSIONS: The FX method may be an additional targeting strategy in patients undergoing thalamic DBS surgery.
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