Journal
EUROPEAN JOURNAL OF NEUROSCIENCE
Volume 41, Issue 10, Pages 1294-1310Publisher
WILEY-BLACKWELL
DOI: 10.1111/ejn.12882
Keywords
axonal arborisation; extrageniculate pathway; lateral posterior nucleus of the thalamus; Sindbis virus; single-neuron labeling
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Funding
- Ministry of Education, Culture, Sports, Science and Technology (MEXT) [25123709, 22110007, 23115101, 24500408, 25250006]
- Japan Society for the Promotion of Science (JSPS)
- Grants-in-Aid for Scientific Research [15H01430, 24500408, 22110007, 15K14333, 25250006] Funding Source: KAKEN
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The lateral posterior thalamic nucleus (LP) is one of the components of the extrageniculate pathway in the rat visual system, and is cytoarchitecturally divided into three subdivisions - lateral (LPl), rostromedial (LPrm), and caudomedial (LPcm) portions. To clarify the differences in the dendritic fields and axonal arborisations among the three subdivisions, we applied a single-neuron labeling technique with viral vectors to LP neurons. The proximal dendrites of LPl neurons were more numerous than those of LPrm and LPcm neurons, and LPrm neurons tended to have wider dendritic fields than LPl neurons. We then analysed the axonal arborisations of LP neurons by reconstructing the axon fibers in the cortex. The LPl, LPrm and LPcm were different from one another in terms of the projection targets - the main target cortical regions of LPl and LPrm neurons were the secondary and primary visual areas, whereas those of LPcm neurons were the postrhinal and temporal association areas. Furthermore, the principal target cortical layers of LPl neurons in the visual areas were middle layers, but that of LPrm neurons was layer 1. This indicates that LPl and LPrm neurons can be categorised into the core and matrix types of thalamic neurons, respectively, in the visual areas. In addition, LPl neurons formed multiple axonal clusters within the visual areas, whereas the fibers of LPrm neurons were widely and diffusely distributed. It is therefore presumed that these two types of neurons play different roles in visual information processing by dual thalamocortical innervation of the visual areas.
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