Journal
CHEMICAL COMMUNICATIONS
Volume 53, Issue 43, Pages 5870-5873Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7cc02466e
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Funding
- Macau Science and Technology Development Fund [FDCT/020/2015/A1, FDCT/066/2015/A2]
- Research Committee of University of Macau [MYRG2016-00165-ICMS-QRCM, MYRG2016-00073-FHS, MYRG2016-00199-FHS]
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We report an unprecedented, eco-friendly, in situ activatable model antibiotic, phenylalanyl-polyethylenimine (PhePEI), to potentially diminish antibiotic pollution of the environment and associated antibiotic resistance. The inactive PhePEI can be reversibly activated upon supramolecular crosslinking by cucurbit[8]uril, conferring potent antibacterial activity.
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