Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 56, Issue 22, Pages 6268-6271Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201611570
Keywords
homogeneous catalysis; diazaphospholenes; imines; phosphorus hydrides; reduction
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Funding
- Dalhousie University
- NSERC (USRA)
- NSERC (CGS-M)
- Nova Scotia Innovation and Research Scholarship
- Killam Foundation
- Nova Scotia Black and First Nations Entrance Scholarship
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The first examples of 1,3,2-diazaphospholene-catalyzed imine reduction and conjugate reduction reactions are reported. This approach employs readily synthesized alkoxydiazaphospholene precatalysts that can be handled in open air. Reduction of substrates containing Lewis basic functionality, isolated unsaturation, and protic functional groups was accomplished. The synthetic utility of this approach is demonstrated by the synthesis of the important antiparkinson medicine rasagiline and the natural product zingerone.
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