Journal
CARBOHYDRATE POLYMERS
Volume 167, Issue -, Pages 1-11Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2017.03.006
Keywords
Chitosan; Degradation; Plasma treatment; Oxidizing agent; Chitooligosaccharide
Categories
Funding
- Thailand Research Fund (TRF) [PHD/0179/2556, BRG5480008]
- Drug Discovery Development center at Thammasat University (Thailand)
Ask authors/readers for more resources
Solution plasma (SP) treatment in combination with oxidizing agents, i.e., hydrogen peroxide (H2O2), potassium persulfate (K2S2O8) and sodium nitrite (NaNO2) were adopted to chitosan degradation in order to achieve fast degradation rate, low chemicals used and high yield of low-molecular-weight chitosan and chitooligosaccharide (COS). Among the studied oxidizing agents, H2O2 was found to be the best choice in terms of appreciable molecular weight reduction without major change in chemical structure of the degraded products of chitosan. By the combination with SP treatment, dilute solution of H2O2 (4-60 mM) was required for effective degradation of chitosan. The combination of SP treatment and dilute solution of H2O2 (60 mM) resulted in the great reduction of molecular weight of chitosan and water-soluble chitosan was obtained as a major product. The resulting water-soluble chitosan was precipitated to obtain COS. An inhibitory effect against cervical cancer cell line (HeLa cells) of COS was also examined. (C) 2017 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available