Journal
THERANOSTICS
Volume 7, Issue 15, Pages 3667-3689Publisher
IVYSPRING INT PUBL
DOI: 10.7150/thno.19365
Keywords
Albumin; Nanoparticle; Drug delivery; Bioimaging; Theranostics; Multifunctional
Categories
Funding
- National Basic Research Program of China (973 Program) [2013CB933500]
- Key Program of the National Natural Science Foundation of China [51533005]
- Major Research Plan of the National Natural Science Foundation of China [91333208]
- Collaborative Innovation Center of Suzhou Nano Science and Technology
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- 111 Project
- Qing Lan Project
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Biosafety is the primary concern in clinical translation of nanomedicine. As an intrinsic ingredient of human blood without immunogenicity and encouraged by its successful clinical application in Abraxane, albumin has been regarded as a promising material to produce nanoparticles for bioimaging and drug delivery. The strategies for synthesizing albumin-based nanoparticles could be generally categorized into five classes: template, nanocarrier, scaffold, stabilizer and albumin-polymer conjugate. This review introduces approaches utilizing albumin in the preparation of nanoparticles and thereby provides scientists with knowledge of goal-driven design on albumin-based nanomedicine.
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