Journal
THERANOSTICS
Volume 7, Issue 10, Pages 2575-2592Publisher
IVYSPRING INT PUBL
DOI: 10.7150/thno.20118
Keywords
Cell membrane; Nanoparticle; Camouflage; Cancer
Categories
Funding
- National Basic Research Program of China [2014CB931900]
- National Natural Science Foundation of China [81521005, 81630052, 81671808]
- Key scientific research program of CAS [QYZDJ-SSW-SMC020]
- Shanghai Pujiang Program [15PJ1409900]
- Youth Innovation Promotion Association of CAS [2017335]
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Cancer is one of the leading causes of death worldwide. Many treatments have been developed so far, although effective, suffer from severe side effects due to low selectivity. Nanoparticles can improve the therapeutic index of their delivered drugs by specifically transporting them to tumors. However, their exogenous nature usually leads to fast clearance by mononuclear phagocytic system. Recently, cell membrane-camouflaged nanoparticles have been investigated for cancer therapy, taking advantage of excellent biocompatibility and versatile functionality of cell membranes. In this review, we summarized source materials and procedures that have been used for constructing and characterizing biomimetic nanoparticles with a focus on their application in cancer therapy.
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