Journal
THERANOSTICS
Volume 7, Issue 6, Pages 1663-1673Publisher
IVYSPRING INT PUBL
DOI: 10.7150/thno.17886
Keywords
glioma; miR-200c; moesin
Categories
Funding
- National Key Research and Development Program of China (Stem Cell and Translational Research) [2016YFA0101202]
- MOST [2015CB553800]
- NSFC [81530075, 81472741, 81322033]
- Science and Technology Project grant from Anhui Province [1506c085017, 1606c08235, 1604a0802069]
- Fundamental Research Funds for the Central Universities [WK2070000034]
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We attempt to demonstrate the regulatory role of miR-200c in glioma progression and its mechanisms behind. Here, we show that miR-200c expression was significantly reduced in the glioma tissues compared to paratumor tissues, especially in malignant glioma. Exogenous overexpression of miR-200c inhibited the proliferation and invasion of glioma cells. In addition, the in vivo mouse xenograft model showed that miR-200c inhibited glioma growth and liver metastasis, which is mainly regulated by targeting moesin (MSN). We demonstrated that the expression of MSN in glioma specimens were negatively correlated with miR-200c expression, and MSN overexpression rescued the phenotype about cell proliferation and invasion induced by miR-200c. Moreover, knockdown of MSN was able to mimic the effects induced by miR-200c in glioma cells. These results indicate that miR-200c plays an important role in the regulation of glioma through targeting MSN.
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