Journal
THERANOSTICS
Volume 7, Issue 13, Pages 3387-3397Publisher
IVYSPRING INT PUBL
DOI: 10.7150/thno.19748
Keywords
electrical cues; piezoelectricity; bone; tissue regeneration; stem cells
Categories
Funding
- National High Technology Research and Development Program of China (863 Program) [2015AA033502]
- National Natural Science Foundation of China [51372087, 51232002, 51541201, 51673168]
- Science and Technology Planning Project of Guangdong Province, China [2014A010105048]
- Natural Science Foundation of Guangdong Province [2015A030313493, 2016A030308014]
- State Key Laboratory for Mechanical Behavior of Materials, China [20141607]
- National Institutes of Health [CA200504, CA195607, EB021339]
- Oklahoma Center for Adult Stem Cell Research [434003]
- Oklahoma Center for the Advancement of Science and Technology [HR14-160]
Ask authors/readers for more resources
The extracellular matrix of bone can be pictured as a material made of parallel interspersed domains of fibrous piezoelectric collagenous materials and non-piezoelectric non-collagenous materials. To mimic this feature for enhanced bone regeneration, a material made of two parallel interspersed domains, with higher and lower piezoelectricity, respectively, is constructed to form microscale piezoelectric zones (MPZs). The MPZs are produced using a versatile and effective laser-irradiation technique in which K0.5Na0.5NbO3 (KNN) ceramics are selectively irradiated to achieve microzone phase transitions. The phase structure of the laser-irradiated microzones is changed from a mixture of orthorhombic and tetragonal phases (with higher piezoelectricity) to a tetragonal dominant phase (with lower piezoelectricity). The microzoned piezoelectricity distribution results in spatially specific surface charge distribution, enabling the MPZs to bear bone-like microscale electric cues. Hence, the MPZs induce osteogenic differentiation of stem cells in vitro and bone regeneration in vivo even without being seeded with stem cells. The concept of mimicking the spatially specific piezoelectricity in bone will facilitate future research on the rational design of tissue regenerative materials.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available