Journal
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE
Volume 20, Issue 3, Pages 186-190Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MCO.0000000000000360
Keywords
aging; atrophy; autophagy; capillarization; exercise; satellite cells
Categories
Funding
- Natural Science and Engineering Research Council of Canada Discovery
Ask authors/readers for more resources
Purpose of review The review is an update on recent research investigating the role of skeletal muscle stem cells (also known as satellite cells) during muscle fiber regeneration and growth in animal and human skeletal muscle, with an emphasis on their role in age-related sarcopenia. Recent findings Studies indicate clear impairments in satellite cell function with aging, resulting in an impaired muscle fiber regenerative response. The autophagy-mediated switch to an irreversible presenescent state of geriatric satellite cells appears to play a key role in age-related impaired satellite cell function. In addition, inadequate muscle fiber vascularization may be a crucial factor underlying impaired regulation of satellite cells in older adults. Controversy remains on the actual contribution of satellite cells to the development of sarcopenia in later life, this clearly requires further research. Nevertheless, exercise training remains to be a potent intervention strategy, mediated through satellite cells or not, to counteract the ill effects of sarcopenia. Summary Although important strides are made investigating the importance of satellite cells in the development and/ or treatment of sarcopenia, the idea that satellite cell function is a therapeutic target to treat sarcopenia remains controversial.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available