Journal
EUROPEAN JOURNAL OF NEUROLOGY
Volume 22, Issue 7, Pages 1138-1141Publisher
WILEY-BLACKWELL
DOI: 10.1111/ene.12722
Keywords
magnetic resonance imaging; multiple sclerosis; neuroprotection; optical coherence tomography
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Funding
- Multiple Sclerosis International Federation through a McDonald Fellowship
- National MS Society [RG3932-A-2]
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Background and purposeThe lack of surrogates of clinical progression has limited the design of neuroprotection trials in multiple sclerosis (MS). Our aim was to study the association between time-domain optical coherence tomography measures and clinical and magnetic resonance imaging outcomes in early MS. MethodsForty-three relapsing-remitting MS patients within 1 year of onset were followed for up to 3years. ResultsThe peripapillary retinal nerve fiber layer (RNFL) decreased annually by 2m (95% confidence interval -3.89, -0.11; P=0.038). The RNFL tended to be associated with normalized normal appearing white matter volume in cross-sectional (P=0.08) and longitudinal analyses (P=0.06). ConclusionsThere is substantial RNFL loss even in very early MS. Our data suggest that retinal axonal atrophy is associated with atrophy in global white matter volume in early MS.
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