Journal
CURRENT PHARMACEUTICAL DESIGN
Volume 23, Issue 11, Pages 1575-1588Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1381612823666170124111142
Keywords
Biopharmaceuticals; bilosomes; proteins and peptides; oral delivery; lymphatic transport
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With the advent of novel vesicular drug delivery systems especially bilosomes, for large molecular weight proteins and peptides, their oral administration seems a viable approach. These nano-vesicles have shown promising results for the effective delivery of insulin and other therapeutics, perhaps due to their structural composition. The present review has elaborated the biopharmaceutical challenges for the oral delivery of therapeutic proteins and peptides as well as presented a novel approach to deliver the essential macromolecules through oral route as bilosomes. The extensive search has been presented related to the formulation, evaluation and in vivo performance of bilosomes. Some of the crucial findings related to bilosomes have corroborated them superior to other colloidal carriers. The successful drug delivery through bilosomes requires significant justifications related to their interaction with the biological membranes. The other aspects such as absolute absorption, safety and toxicity of bilosome drug delivery should also be equally considered.
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