Journal
BULGARIAN CHEMICAL COMMUNICATIONS
Volume 49, Issue -, Pages 71-75Publisher
BULGARIAN ACAD SCIENCE
Keywords
resveratrol; benzoxazolone; stilbene; cytotoxicity
Categories
Funding
- Sofia University Scientific Research Fund [85/2009, 99/2011]
- University of Forestry, Sofia, Bulgaria [12/19.01.2016]
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New heterocycle analogues of resveratrol were designed and synthesized as potential anticancer agents. The compounds contain 3,5-dimethoxy-or 3,5-dihydroxystyryl fragment attached to the C5 or C6 position of a benzoxazolone ring. The compounds were tested for their cytotoxic activity against three human cancer cell lines (HL60, MGF-7 and MDA-MB-321) and some of them were found to exhibit significant antiproliferative effect. Generally, the obtained 5-styrylbenzoxazolones were more active in compare to the corresponding 6-styrylbenzoxazolone positional isomers.
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