Journal
SCIENTIFIC REPORTS
Volume 7, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41598-017-02542-1
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Funding
- NIMH Grant [RO1 62122]
- NINDS Ruth L. Kirschstein National Research Service Award [T32 - NS058280]
- Narsad Distinguished Investigator Award [18667]
- Staglin Music Festival Center for Brain and Behavioral Health
- Tobacco-Related Disease Research Program Project [22RT-0103]
- Brain & Behavior Research Foundation [21517]
- ARCS Foundation
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Learning about context is essential for appropriate behavioral strategies, but important contingencies may not arise during initial learning. A variant of contextual fear conditioning, context pre-exposure facilitation, allows us to directly test the relationship between novelty-induced acetylcholine release and later contextual associability. We demonstrate that optogenetically-enhanced acetylcholine during initial contextual exploration leads to stronger fear after subsequent pairing with shock, suggesting that novelty-induced acetylcholine release primes future contextual associations.
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