Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 89, Issue -, Pages 421-441Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2014.10.065
Keywords
Indole; Antiviral activity; Entry and fusion inhibitor; Reverse transcriptase inhibitor; Integrase inhibitor; Protease inhibitor; Polymerase inhibitor; Natural product
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Funding
- National Key Technologies RD Program [2011BAE06B05]
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Indole represents one of the most important privileged scaffolds in drug discovery. Indole derivatives have the unique property of mimicking the structure of peptides and to bind reversibly to enzymes, which provide tremendous opportunities to discover novel drugs with different modes of action. There are seven indole-containing commercial drugs in the Top-200 Best Selling Drugs by US Retail Sales in 2012. There are also an amazing number of approved indole-containing drugs in the market as well as compounds currently going through different clinical phases or registration statuses. This review focused on the recent development of indole derivatives as antiviral agents with the following objectives: 1) To present one of the most comprehensive listings of indole antiviral agents, drugs on market or compounds in clinical trials; 2) To focus on recent developments of indole compounds (including natural products) and their antiviral activities, summarize the structure property, hoping to inspire new and even more creative approaches; 3) To offer perspectives on how indole scaffolds as a privileged structure might be exploited in the future. (C) 2014 Elsevier Masson SAS. All rights reserved.
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