Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 105, Issue -, Pages 57-62Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2015.10.006
Keywords
Sapindus saponaria; Pentacyclic triterpenes; Hederagenin derivatives; SRB assay; Folk medicinal plant
Categories
Funding
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [304341/2013-4]
- Fundacao de Amparo a Pesquisa de Minas Gerais (FAPEMIG) [APQ-00276-13]
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
- Grunderwerkstatt - Biowissenschaften
Ask authors/readers for more resources
In this study, a series of novel C-28 esters and amides derivatives of hederagenin (He) were designed and synthesized in attempt to develop potent antitumor agents. Their structures were confirmed by MS, IR, H-1 NMR and C-13 NMR spectroscopic analyses and their cytotoxic activities were screened in SRB assays using a panel of six human cancer cell lines. Although most of the compounds displayed moderate to high levels of cytotoxic activity they were all more potent than the natural product He. The most active compounds had either an ethylpyrimidinyl (27) or an ethylpyrrolidinyl (28) substituent, with EC50 in the range of 1.1-6.5 mu M for six human cancer cell lines. Notably, this corresponds to an approximately 30-fold times greater potency than He. (C) 2015 Elsevier Masson SAS. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available