Journal
BIOCHEMICAL PHARMACOLOGY
Volume 133, Issue -, Pages 29-42Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bcp.2016.12.015
Keywords
Antibiotic; Non-coding RNA; Ribosome; tRNA; Riboswitch
Categories
Funding
- NSERC Discovery Grant [04681]
- NSERC Discovery Accelerator Supplement
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Antibiotics inhibit a wide range of essential processes in the bacterial cell, including replication, transcription, translation and cell wall synthesis. In many instances, these antibiotics exert their effects through association with non-coding RNAs. This review highlights many classical antibiotic targets (e.g. rRNAs and the ribosome), explores a number of emerging targets (e.g. tRNAs, RNase P, riboswitches and small RNAs), and discusses the future directions and challenges associated with non-coding RNAs as antibiotic targets. (C) 2016 Elsevier Inc. All rights reserved.
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