Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 38, Issue -, Pages 108-116Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2017.03.013
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Funding
- National Science Foundation [CHE 1306447]
- Research Scholar Award from the American Cancer Society [128319-RSG-15-144-01-CDD]
- NIH [T32 GM007250, TL1 TR000441]
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There are a wide variety of synthetic and naturally occurring nanomaterials under development for nanoscale cargo delivery applications. Viruses play a special role in these developments, because they can be regarded as naturally occurring nanomaterials evolved to package and deliver cargos. While any nanomaterial has its advantage and disadvantages, viral nanoparticles (VNPs), in particular the ones derived from plant viruses and bacteriophages, are attractive options for cargo-delivery as they are biocompatible, biodegradable, and non-infectious to mammals. Their protein based structures are often understood at atomic resolution and are amenable to modification with atomic-level precision through chemical and genetic engineering. Here we present a focused review of the emerging technology development of plant viruses and bacteriophages targeting human health and agricultural applications. Key target areas of development are their use in chemotherapy, photodynamic therapy, pesticide delivery, gene therapy, vaccine carriers, and immunotherapy.
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