Journal
JOURNAL OF BREATH RESEARCH
Volume 11, Issue 2, Pages -Publisher
IOP Publishing Ltd
DOI: 10.1088/1752-7163/aa7143
Keywords
exhaled breath analysis; VOC; SIFT-MS; ESRD
Categories
Funding
- Ohio Department of Development [BRCP 08-049]
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Many uremic solutes retained in chronic kidney disease are volatile, and can be detected by breath testing. Wecompared the exhaled breath of subjects with end stage renal disease (ESRD) to healthy volunteers to identify volatile compounds that can serve as a potential breathprint for renal failure. We analyzed the exhaled breath of 86 ESRD subjects and 25 healthy volunteers using selected-ion flowtube mass spectrometry (SIFT-MS). Using a random forests classification model, we identified three known volatiles (2-propanol, ammonia, acetaldehyde) and two unknown volatiles (O(2)(+)50, NO(+)76) that were highly significant for discriminating individuals with renal failure from individuals without renal failure (Cstatistic > 0.99). This study provides preliminary support for the use of exhaled breath as a potential noninvasive screening tool in renal failure.
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