Journal
BIOMATERIALS
Volume 128, Issue -, Pages 69-83Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2017.02.041
Keywords
Cell membrane; Biomimetic nanoparticle; Drug delivery; Immunotherapy; Detoxification; Imaging
Funding
- National Institutes of Health [R01CA200574]
- National Science Foundation [DMR-1505699]
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [1505699] Funding Source: National Science Foundation
Ask authors/readers for more resources
The continued evolution of biomedical nanotechnology has enabled clinicians to better detect, prevent, manage, and treat human disease. In order to further push the limits of nanoparticle performance and functionality, there has recently been a paradigm shift towards biomimetic design strategies. By taking inspiration from nature, the goal is to create next-generation nanoparticle platforms that can more effectively navigate and interact with the incredibly complex biological systems that exist within the body. Of great interest are cellular membranes, which play essential roles in biointerfacing, self identification, signal transduction, and compartmentalization. In this review, we explore the major ways in which researchers have directly leveraged cell membrane-derived biomaterials for the fabrication of novel nanotherapeutics and nanodiagnostics. Such emerging technologies have the potential to significantly advance the field of nanomedicine, helping to improve upon traditional modalities while also enabling novel applications. (C) 2017 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available