Journal
SCIENTIFIC REPORTS
Volume 7, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41598-017-16494-z
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Funding
- Thermo Scientific
- Natural Sciences and Engineering Research Council (NSERC) of Canada through the Industrial Research Chair program
- Pfizer Canada Inc.
- Merck Canada Inc.
- Quebec Consortium for Drug Discovery (CQDM)
- Brain Canada
- Ontario Brain Institute
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This study demonstrates the quantitative capabilities of coated blade spray (CBS) mass spectrometry (MS) for the concomitant analysis of multiple target substances in biofluid spots. In CBS-MS the analytes present in a given sample are first isolated and enriched in the thin coating of the CBS device. After a quick rinsing of the blade surface, as to remove remaining matrix, the analytes are quickly desorbed with the help of a solvent and then directly electrosprayed into the MS analyzer. Diverse pain management drugs, controlled substances, and therapeutic medications were successfully determined using only 10 mu L of biofluid, with limits of quantitation in the low/sub ng.mL(-1) level attained within 7 minutes.
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