Journal
EUROPEAN CYTOKINE NETWORK
Volume 28, Issue 2, Pages 41-51Publisher
JOHN LIBBEY EUROTEXT LTD
DOI: 10.1684/ecn.2017.0394
Keywords
flavivirus; inflammation; signalling pathway; RIG-I; TLR3; MDA5
Ask authors/readers for more resources
Skin is a complex organ and the largest interface of the human body exposed to numerous stress and pathogens. Skin is composed of different cell types that together perform essential functions such as pathogen sensing, barrier maintenance and immunity, at once providing the first line of defense against microbial infections and ensuring skin homeostasis. Being inoculated directly through the epidermis and the dermis during a vector blood meal, emerging Dengue, Zika and West Nile mosquito-borne viruses lead to the initiation of the innate immune response in resident skin cells and to the activation of dendritic cells, which migrate to the draining lymph node to elicit an adaptive response. This literature review aims to describe the inflammatory response and the innate immune signalization pathways involved in human skin cells during Dengue, Zika and West Nile virus infections.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available