Journal
ACTA VETERINARIA-BEOGRAD
Volume 67, Issue 2, Pages 137-152Publisher
SCIENDO
DOI: 10.1515/acve-2017-0013
Keywords
anthelmintic; parasite; benzimidazoles; avermectins; cholinergic; emodepside; derquantel
Categories
Funding
- NIH [R21AI121831-01, R01AI047194]
- Schlumberger Foundation Faculty for the Future Program
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Anthelmintics are some of the most widely used drugs in veterinary medicine. Here we review the mechanism of action of these compounds on nematode parasites. Included are the older classes of compounds; the benzimidazoles, cholinergic agonists and macrocyclic lactones. We also consider newer anthelmintics, including emodepside, derquantel and tribendimidine. In the absence of vaccines for most parasite species, control of nematode parasites will continue to rely on anthelmintic drugs. As a consequence, vigilance in detecting drug resistance in parasite populations is required. Since resistance development appears almost inevitable, there is a continued and pressing need to fully understand the mode of action of these compounds. It is also necessary to identify new drug targets and drugs for the continued effective control of nematode parasites.
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