Journal
CURRENT OPINION IN MICROBIOLOGY
Volume 37, Issue -, Pages 110-119Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2017.05.010
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Funding
- National Institutes of Health [P20GM103500, P30GM110732-03, R01G1M110270, R01GM108888]
- National Science Foundation EPSCoR [EPS-110134]
- M.J. Murdock Charitable Trust
- Amgen
- Gordon and Betty Moore Foundation
- Montana State University Agricultural Experimental Station and Montana University System Research Initiative [51040-MUSRI2015-03]
- Utah State University from the Department of Chemistry and Biochemistry
- Research and Graduate Studies Office
- College of Science
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Adaptive immune systems in bacteria and archaea rely on small CRISPR-derived RNAs (crRNAs) to guide specialized nucleases to foreign nucleic acids. The activation of these nucleases is controlled by a series of molecular checkpoints that ensure precise cleavage of nucleic acid targets, While minimizing toxic off-target cleavage events. In this review, we highlight recent advances in understanding regulatory mechanisms responsible for controlling the activation of these nucleases and identify emerging regulatory themes conserved across diverse CRISPR systems.
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