Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 97, Issue -, Pages 462-482Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2014.11.043
Keywords
Azaheterocycle; Phthalazin-1(2H)-one; Synthesis; Pharmacological activity; Bioactive compound; Biological target
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Funding
- Xunta de Galicia [CN2012/184]
- Universidade de Vigo
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Phthalazinones are an important kind of nitrogen atom containing heterocyclic compounds due to their synthetic and pharmacological versatility. This fused heterocycle system represents a common structural feature for many bioactive compounds showing a variety of pharmacological activities such as anticancer, anti-diabetic, anti-asthmatic, antihistaminic, antihypertensive, antithrombotic, anti-inflammatory, analgesic, antidepressant or antimicrobial agents, which makes it an attractive scaffold for the design and development of new drugs. This review summarizes detailed and updated information, described in recent non-patent literature, about the most relevant pharmacological properties of phthalazinone derivatives, highlighting the application of this potent pharmacophore in drug discovery. (C) 2014 Elsevier Masson SAS. All rights reserved.
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