Journal
SCIENTIFIC REPORTS
Volume 7, Issue -, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/srep43632
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Funding
- Professor of Chang Jiang Scholars Program
- National Natural Science Foundation of China [61372194, 81260672, 8130090, 81473327, 81520108030, 81573318, 81373301, 81302658]
- Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products [10DZ2251300]
- Scientific Foundation of Shanghai China [12401900801, 13401900103, 13401900101]
- National Major Project of China [2011ZX09307-002-03]
- National Key Technology RAMP
- D Program of China [2012BAI29B06]
- Chongqing Education Reform Project of Graduate [yjg152017]
- Graduate student research and innovation funding project of Chongqing China [CYB16129]
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Shexiang Baoxin Pill (SBP), a traditional Chinese medicine formula, is commonly used to treat cardiovascular disease (CVD) in China. However, the complexity of composition and targets has deterred our understanding of its mechanism of action. Using network pharmacology-based approaches, we established the mechanism of action for SBP to treat CVD by analyzing protein-protein interactions and pathways. The computational results were confirmed at the gene expression level in microarray-based studies. Two of the SBP's targets were further confirmed at the protein level by Western blot. In addition, we validated the theory that SBP's plasma absorbed compounds play major therapeutic role in treating CVD.
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