Journal
ANALYTICA CHIMICA ACTA
Volume 970, Issue -, Pages 1-22Publisher
ELSEVIER
DOI: 10.1016/j.aca.2017.03.037
Keywords
Paper-based devices; Point-of-care testing (POCT); Colorimetric assays; Microfluidics; Colorimetric detection
Categories
Funding
- FAPESP [2011/13997-8]
- CNPq [131306/2013-8, 205453/2014-7]
- Instituto Nacional de Ciencia e Tecnologia de Bioanalitica - INCTBio (FAPESP Grant) [2008/57805-2/CNPq, 573672/2008-3]
- Georgia Institute of Technology (Georgia Tech)
- State of Georgia, USA
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Paper-based devices are a leading alternative among the main analytical tools for point-of-care testing, due to their portability, low-cost, and ease-of-use. Colorimetric readouts are the most common method of detection in these microfluidic devices, enabling qualitative, semi-quantitative and fully quantitative analysis of multiple analytes. There is a multitude of ways to obtain a colorimetric output in such devices, including nanoparticles, dyes, redox and pH indicators, and each has unique drawbacks and benefits. There are also multiple variables that impact the analysis of colorimetric reactions in microfluidic paperbased systems, including color homogeneity, image capture methods, and the data handling itself. Here, we present a critical review of recent developments and challenges of colorimetric detection on microfluidic paper-based analytical devices (mu PADs), and present thoughts and insights towards future perspectives in the area to improve the use of colorimetric readouts in conjunction with mu PADs. (C) 2017 Elsevier B.V. All rights reserved.
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