Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 46, Issue -, Pages 127-133Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2017.07.013
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Funding
- NIFI [U19 AI11124, R0l A1049313, R0l AR048632]
- Bill and Melinda Gates Foundation
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CD1a, CD1b, CD1c and CD1d proteins migrate through distinct subcellular compartments of antigen presenting cells and so can be considered to take four separate pathways leading to display of lipid antigens to T cell receptors. This review discusses the intersection of CD1 trafficking and lipid antigen loading mechanisms in cells, highlighting key controversies relating to CD1 gene expression, size mismatches between antigens and CD1 binding clefts and unexpected mechanisms of T cell receptor-based recognition.
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