Journal
CURRENT OPINION IN NEUROBIOLOGY
Volume 44, Issue -, Pages 80-88Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2017.03.009
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Funding
- National Institutes of Health [NS070911, NS094390, NS095824, NS082010]
- Mallinckrodt Foundation
- Rita Allen Foundation
- Brain and Behavior Research Foundation
- Della Martin Foundation
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Sleep consumes a third of our lifespan, but we are far from understanding how it is initiated, maintained and terminated, or what purposes it serves. To address these questions, alternative model systems have recently been recruited. The diurnal zebrafish holds the promise of bridging the gap between simple invertebrate systems, which show little neuroanatomical conservation with mammals, and well established, but complex and nocturnal, murine systems. Zebrafish larvae can be monitored in a high-throughput fashion, pharmacologically tested by adding compounds into the water, genetically screened using transient transgenesis, and optogenetically manipulated in a non-invasive manner. Here we discuss work that has established the zebrafish as a powerful system for the study of sleep, as well as novel insights gained by exploiting its particular advantages.
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