Journal
CURRENT OPINION IN CHEMICAL BIOLOGY
Volume 38, Issue -, Pages 52-61Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.cbpa.2017.02.020
Keywords
-
Categories
Funding
- Japan Science and Technology Agency (JST) Core Research for Evolutional Science and Technology (CREST) of Molecular Technologies
- Japan Society for the Promotion of Science (JSPS) [26220204]
- European Union's Horizon research and innovation programme [657292]
- [P15333]
- Marie Curie Actions (MSCA) [657292] Funding Source: Marie Curie Actions (MSCA)
- Grants-in-Aid for Scientific Research [15F15333, 26220204] Funding Source: KAKEN
Ask authors/readers for more resources
From their early roots in natural products, peptides now represent an expanding class of novel drugs. Their modular structures make them ideal candidates for pooled library screening approaches. Key technologies for library generation and screening, such as SICLOPPS, phage display and mRNA display, give unparalleled access to tight binding peptides. Through combination with genetic code reprogramming and chemical modifications, access to more natural product-like libraries, spanning non-canonical peptide space, is readily achievable. Recent advances in these fields enable introduction of diverse non-standard motifs, such as cyclisation and backbone methylations. Peptide discovery platforms now allow robust access to potent, highly functionalised peptides against virtually any protein of interest, with typical binding constants in the nanomolar range. Application of these optimised platforms in a drug discovery setting has the potential to significantly accelerate identification of new leads.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available