Journal
SCIENTIFIC REPORTS
Volume 7, Issue -, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/srep40482
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Funding
- National Natural Science Foundation of China [81402743]
- National Key Research and Development Program of China [2016YFC0200900]
- Hubei Province Health and Family Planning Scientific Research Project [WJ2015Q023]
- Fundamental Research Funds for the Central Universities [2042016kf0165]
- China Postdoctoral Science Foundation [2015M572198]
- program of Key Laboratory for National Geographic Census and Monitoring, National Administration of Surveying, Mapping and Geoinformation [2014NGCM]
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Few studies have compared different methods when exploring the short-term effects of air pollutants on respiratory disease mortality in Wuhan, China. This study assesses the association between air pollutants and respiratory disease mortality with both time-series and time-stratified-case-crossover designs. The generalized additive model (GAM) and the conditional logistic regression model were used to assess the short-term effects of air pollutants on respiratory disease mortality. Stratified analyses were performed by age, sex, and diseases. A 10 mu g/m(3) increment in SO2 level was associated with an increase in relative risk for all respiratory disease mortality of 2.4% and 1.9% in the case-crossover and time-series analyses in single pollutant models, respectively. Strong evidence of an association between NO2 and daily respiratory disease mortality among men or people older than 65 years was found in the case-crossover study. There was a positive association between air pollutants and respiratory disease mortality in Wuhan, China. Both time-series and case-crossover analyses consistently reveal the association between three air pollutants and respiratory disease mortality. The estimates of association between air pollution and respiratory disease mortality from the case-crossover analysis displayed greater variation than that from the time-series analysis.
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