Journal
COLLOIDS AND SURFACES B-BIOINTERFACES
Volume 154, Issue -, Pages 63-73Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.colsurfb.2017.03.018
Keywords
Quercetin; Calcium phosphate nanoparticle; pH-sensitive properties; Fluorophore; Antioxidant
Funding
- SR/NM/NS-1461/2014(G) DST-Nanomission
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Calcium phosphate quercetin nanocomposite (CPQN) i.e., quercetin entrapped in calcium phosphate nanoparticle was synthesized by a precipitation method at 80 degrees C, taking ammonium hydrogen phosphate, calcium nitrate and quercetin as precursors and sodium citrate as stabilizer. The nanocomposite suspension had different color at different pH values, a property that could render the nanoparticle a pH indicator. Besides color, the particles also had different size, shape, stability and quercetin content with change of pH. In addition, the CPQN was highly fluorescent having two sharp emission peaks at 460 and 497nm, when excited at 370nm; by this property it behaved as an effective fluorophore to label biological cell. Moreover, the nanocomposite had potential anti-oxidant property, for which mortality of mouse neuroblastoma cell N2A, by H2O2-induced oxidative stress, was found to be lowered by the pre-treatment of the cells with CPQN. 2017 Elsevier B.V. All rights reserved.
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