Journal
CURRENT OPINION IN MICROBIOLOGY
Volume 37, Issue -, Pages 150-154Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.mib.2017.08.003
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Funding
- Rita Allen Scholars Program
- Burroughs Wellcome Fund PATH Award
- NIH Director's New Innovator Award [1DP2AI104556-01]
- HHMI-Simons Faculty Scholar Award
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Type III CRISPR-Cas systems have a unique targeting mechanism that requires the transcription of the DNA target and results in the degradation of not only the genome of the invader but also its transcripts. Here we discuss the most recent studies describing dual DNA and RNA targeting by these systems, as well as the implications of this complex molecular mechanism for immunity in vivo.
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