Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
Volume 1864, Issue 6, Pages 865-876Publisher
ELSEVIER
DOI: 10.1016/j.bbamcr.2017.01.001
Keywords
Organelle communication; Mitochondria-associated membranes (MAM); Calcium signaling; Liver; Insulin resistance; Type 2 diabetes mellitus; NAFLD
Categories
Funding
- INSERM
- National Research Agency [ANR-09-JCJC-0116, ANR-11-BSV1-033-02]
- Fondation pour la recherche medicale [DRM20101220461]
- Servier Laboratories [RPL11002CCA]
- Agence Nationale de la Recherche (ANR) [ANR-09-JCJC-0116] Funding Source: Agence Nationale de la Recherche (ANR)
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The liver plays a central role in glucose homeostasis, and both metabolic inflexibility and insulin resistance predispose to the development of hepatic metabolic diseases. Mitochondria and endoplasmic reticulum (ER), which play a key role in the control of hepatic metabolism, also interact at contact points defined as mitochondria-associated membranes (MAM), in order to exchange metabolites and calcium (Ca2+) and regulate cellular homeostasis and signaling. Here, we overview the role of the liver in the control of glucose homeostasis, mainly focusing on the independent involvement of mitochondria, ER and Ca2+ signaling in both healthy and pathological contexts. Then we focus on recent data highlighting MAM as important hubs for hormone and nutrient signaling in the liver, thus adapting mitochondria physiology and cellular metabolism to energy availability. Lastly, we discuss how chronic ER-mitochondria miscommunication could participate to hepatic metabolic diseases, pointing MAM interface as a potential therapeutic target for metabolic disorders. This article is part of a Special Issue entitled: ECS Meeting edited by Claus Heizmann, Joachim Krebs and Jacques Haiech. (C) 2017 Elsevier B.V. All rights reserved.
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