Journal
SCIENTIFIC REPORTS
Volume 7, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/srep39848
Keywords
-
Categories
Funding
- Well Aging Research Center
- Samsung Adv. Inst. of Tech. (SAIT)
- Samsung Electronics Co. LTD. Korea
- DGIST R&D Program of the Ministry of Science, ICT and Technology of KOREA [20160172]
- National Research Foundation of Korea (NRF) - Korea government [NRF-2014R1A2A1A10051664]
Ask authors/readers for more resources
Inflammaging is defined as low-grade, chronic, systemic inflammation in aging, in the absence of overt infection. Age-associated deterioration of gastrointestinal function could be ascribed to the inflammaging, although evidence is yet to emerge. Here we show that microvessels in aging mouse intestine were progressively deprived of supportive structures, microvessel-associated pericytes and adherens junction protein vascular endothelial (VE)-cadherin, and became leaky. This alteration was ascribed to up-regulation of angiopoetin-2 in microvascular endothelial cells. Up-regulation of the angiopoietin-2 was by TNF-alpha, originated from M2-like residential CD206(+) macrophages, proportion of which increases as animal ages. It was concluded that antigenic burdens encountered in intestine throughout life create the condition of chronic stage of inflammation, which accumulates M2-like macrophages expressing TNF-alpha. The TNF-alpha induces vascular leakage to facilitate recruitment of immune cells into intestine under the chronic inflammatory setting.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available