Journal
AUTOIMMUNITY REVIEWS
Volume 16, Issue 6, Pages 612-619Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.autrev.2017.04.008
Keywords
Blood-brain-barrier; Neuropsychiatric lupus; SLE; Blood-CSF barrier; Choroid plexus; Glymphatics
Categories
Funding
- NIH [T32-GM007288]
- National Institute of Mental Health [MH108574]
- National Institute of Biomedical Imaging and Bioengineering [EB015902]
- Abisch-Frenkel Foundation [15/H1]
- Leona M. and Harry B. Helmsley Charitable Trust [2015PG-ISL007]
- National Institute of Arthritis and Musculoskeletal Diseases [AR065594]
Ask authors/readers for more resources
Experts have previously postulated a linkage between lupus associated vascular pathology and abnormal brain barriers in the immunopathogenesis of neuropsychiatric lupus. Nevertheless, there are some discrepancies between the experimental evidence, or its interpretation, and the working hypotheses prevalent in this field; specifically, that a primary contributor to neuropsychiatric disease in lupus is permeabilization of the blood brain barrier. In this commonly held view, any contribution of the other known brain barriers, including the blood-cerebrospinal fluid and meningeal barriers, is mostly excluded from the discussion. In this review we will shed light on some of the blood brain barrier hypotheses and try to trace their roots. In addition, we will suggest new research directions to allow for confirmation of alternative interpretations of the experimental evidence linking the pathology of intra-cerebral vasculature to the pathogenesis of neuropsychiatric lupus. (C) 2017 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available